Excipient MultiFunctional C

Identification

Chemical Name

Polyethylene Glycol

Categories

Markets → Healthcare & Pharma → Applications → Pharmaceutical Manufacturing → API Manufacturing

Technologies → Pharmaceuticals & Nutraceuticals → Product Families → Excipients → Carriers & Bulking Agents

Markets → Healthcare & Pharma → Applications → Pharmaceutical Manufacturing → Excipients & Coatings

Markets → Healthcare & Pharma → Applications → Drug Delivery & Care Solutions → Oral

Technologies → Pharmaceuticals & Nutraceuticals → Product Families → Excipients → Other Excipients

Markets → Healthcare & Pharma → Applications → Drug Delivery & Care Solutions → Rectal

Technologies → Pharmaceuticals & Nutraceuticals → Product Families → Excipients → Solvents & Solubilizers

Markets → Healthcare & Pharma → Applications → Drug Delivery & Care Solutions → Topical

Applications

Dosage Form

Capsules,

Ointments,

Soft Gels,

Suppositories

Applications & Uses

Example Application

• The low-molecular weight liquid polyethylene glycols Kollisolv® PEG 300 is excellent solvent for a large number of substances that do not readily dissolve in water. It’s widely used as solvent and solubilising agent for active substances and excipients in liquid and semi-solid preparations. It is the ability of PEGs to form complexes with active substances that is responsible for their excellent solvent power.
• However, equilibrium constants for complex formation vary considerably from one substance to another, and certain drugs such as Penicillin G and Bacitracin can even become inactivated.
• The effect of the polyethylene glycol on the efficacy and absorption of a drug must therefore always be determined in tests. With regard to incompatible substances, please see the remarks in the European Pharmacopeia, Vol. II/3, Monographs M1, Macrogol 300, p. 3.
• Polyethylene glycols can also be used to adjust the viscosity of liquid pharmaceutical preparations and ointments, to modify their absorption properties and to stabilize the preparation. In the manufacture of soft gelatin capsules, liquid macrogol can be used as carrier for dissolved or suspended drugs.
• Mixtures of solid and liquid polyethylene glycols can be used as water-soluble bases for ointments, suppositories and ovula. For burns from chlorophenols or chlorocresols, a mixture of two parts Kollisolv® PEG 300 and one part ethanol is recommended.

Functions

Pharma & Nutraceuticals Functions

Carrier,

Solubilizer,

Solvent,

Suppository Base

Function

Suppository Base, Carrier, Solubilizer, Solvent

Identification & Functionality

Structural Formula

With n = 6, the number in the name of the product indicates its average molecular weight.

Packaging & Availability

Packaging Type

Drums,

Bottles

Packaging Information

• 130 kg Plastic drums
• 0.5 kg Plastic bottle

Properties

Physical Form

Liquid

Technical Properties

Hygroscopicity

At room temperature and 80% r. h. approx. 55% of increase of weight was noted over a period of 42 days.

Viscosity

Temperature: 20 °C – 80 °C
GP: 500 1/s

Dynamic viscosity of Kollisolv® PEG 300

Regulatory & Compliance

Certifications & Compliance

European Pharmacopeia (Ph. Eur.),

FCC Compliant,

United States Pharmacopeia (USP),

Japan Pharmacopeia (JP),

National Formulary (NF)

Grade

Pharma Grade